An animal model of early-stage femoral head osteonecrosis induced by cryo-insult in small tailed Han sheep
نویسندگان
چکیده
منابع مشابه
Emu model of full-range femoral head osteonecrosis induced focally by an alternating freezing and heating insult.
The emu, a large bipedal bird with hip joint biomechanics similar to humans, was used to establish an experimental model of femoral head osteonecrosis and subsequent femoral head collapse. Focal lesions were induced in 20 adult male emus using an alternating liquid nitrogen freezing and radiofrequency heating insult. At 2, 4, 8, 12 and 16 weeks post-surgery, hip magnetic resonance imaging (MRI)...
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BACKGROUND The lack of an experimental animal model that can reliably mimic all stages of osteonecrosis of the femoral head has hindered progress toward the successful prevention and treatment of the disease. MATERIAL/METHODS A goat model of osteonecrosis of the femoral head (ONFH) was established and observed from the early to the intermediate-to-late stage of mechanical failure. Absolute al...
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This was Presented in 5th International Congress of Iranian Iranian Society of Knee Surgery, Arthroscopy, and Sports Traumatology (ISKAST), 14-17 Feb 2018- Kish, Iran
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BACKGROUND Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated. There is a need for a reproducible animal model that better approximates the clinical scenario. METHODS To determine the genetic susceptibility of rats to develop GC-induced femoral head ON, we evaluated 5 different inbred ...
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We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was observed and evaluated by micro-computed tomography (CT) scans and pathology. Osteoblast and osteocl...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Translation
سال: 2021
ISSN: 2214-031X
DOI: 10.1016/j.jot.2020.06.004